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Frankfurt Airport is the main flight gateway for many Rhine, Main and Main-Danube river cruises, and some itineraries begin or end on the Main in the city itself.
The rebuilt old town square and the Main riverfront — the most atmospheric base.
Apple-wine taverns and the Museum Embankment just across the river.
Plenty of affordable hotels by the main station, with direct trains to the airport.
Leafy and upscale, near the Palmengarten and the trade-fair grounds.
Airport hotels for late arrivals and early departures.
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Weekends and summer holidays are often cheapest because business travel drops; major trade fairs send rates sharply higher.
If you land on a long-haul flight, a night in Frankfurt lets you rest before transferring to your ship; the airport and main station areas are the most practical.
The area around the Hauptbahnhof has many budget options, and weekend rates across the city are often lower.
During big trade fairs at the Messe Frankfurt, when rooms across the city fill up.